Prenatal Choline Supplementation and MK-801 Toxicity: Protecting Memory and Preventing Neurodegeneration

نویسنده

  • Chelsea Nickerson
چکیده

....................................................................................................... 3 Introduction................................................................................................... 4 Materials and Methods...................................................................................... 12 Results......................................................................................................... 22 Discussion.................................................................................................... 27 Conclusion.................................................................................................... 35 Figures......................................................................................................... 38 References.................................................................................................... 50 Acknowledgments........................................................................................... 56

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prenatal choline supplementation protects against postnatal neurotoxicity.

Choline, a dietary compound present in many foods, has recently been classified as an essential nutrient for humans. There is evidence from animal models that the availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a 6 d gestational period protects against neurodegeneration in the posterior cingulate ...

متن کامل

Effect of ecstasy microinjection on spatial memory and it’s interaction with glutamatergic system in male rats

Introduction: Ecstasy is an amphetamine derivative, which its use has been consistently increasing over the past years. Ecstasy interacts with the glutamatergic system and it is known that glutamate receptors have a key role in learning and memory. The aim of this study was to investigate the interaction of ecstasy and glutamatergic system on learning and memory. Methods: Fifty-six male Wis...

متن کامل

Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.

The ability of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to prevent neuronal degeneration in the rat striatum and hippocampus caused by intracerebral injection of excitotoxins has been examined. Excitotoxic damage was assessed after 7 d, using histological and biochemical [choline acetyltransferase (ChAT) glutamate decarboxylase (GAD)] measurements. Systemically ...

متن کامل

Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus.

Prenatal choline supplementation (SUP) protects adult rats against spatial memory deficits observed after excitotoxin-induced status epilepticus (SE). To examine the mechanism underlying this neuroprotection, we determined the effects of SUP on a variety of hippocampal markers known to change in response to SE and thought to underlie ensuing cognitive deficits. Adult offspring from rat dams tha...

متن کامل

Protective effects of prenatal choline supplementation on seizure-induced memory impairment.

Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998). We investigated the effects of prenatal choline supplementation on memory deficits associated with status epilepticus. Pregnant rats received a control or choline-supplemented diet during days 11-17 of gestation. Male offspring [postnatal day ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016